Regina arrived at Halifax on January 6, and was commissioned on January 22, 1942. She served with WLEF from mid-March until September, when she was reassigned to Operation "Torch." Crossing as escort to convoy SC.108, she arrived at Belfast on November 22 for refit, following which she was employed as escort to U.K.-Mediterranean convoys. While thus engaged on February 8, 1943, she sank the Italian submarine Avorio in the western Mediterranean, north of Phillipville, Algeria. Returning to Canada late in March, she briefly rejoined WLEF before commencing a refit at Sydney on June 9. The work was completed at Pictou in mid-December and workups carried out there, followed by further repairs at Halifax and Shelburne. Regina joined EG C-1 in February, 1944, and at the beginning of March left Argentia to escort SC.154 to the U.K., but was detached in mid-ocean with Valleyfield to escort an RN tug towing the convoy rescue ship Dundee toward Horta. She left Horta on March 14, this time escorting the damaged HMCS Mulgrave, under tow for the Clyde. Arriving at Londonderry toward the end of March, Regina was assigned to Western Approaches Command for invasion duties. She was employed as an escort to Channel and coastal convoys until August 8, 1944, when she was torpedoed and sunk of Trevose Head, Cornwall, by U 667. Thirty of her ship's company were lost.
Torpedoed and sunk by U667, off Trevose Head, Cornwall, England, 8 Aug 44. Thirty of her ship's company were lost.